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Brand:
Meridia
Pronunciation: mer-ID-dee-uh
Generic Name: Sibutramine hydrochloride
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Meridia helps the seriously overweight shed pounds and
keep them off. It is especially recommended for those who in
addition to being overweight have other health problems such
as high blood pressure, diabetes, or high cholesterol.
It is used in conjunction with a low-calorie diet. Meridia
works by boosting levels of certain chemical messengers in the
nervous system, including serotonin, dopamine, and norepinephrine.
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Make a point of keeping follow-up appointments with your doctor.
Meridia can increase your blood pressure, so it's important
to have your blood pressure and pulse monitored at the beginning
of therapy and regularly thereafter.
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Meridia can be taken with or without food.
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If you miss a dose... Take it as soon as you remember. If
it is almost time for your next dose, skip the one you missed
and go back to your regular schedule. Do not take 2 doses
at once.
Storage
instructions:
Store Meridia at room temperature away from heat and
moisture in a tight, light-resistant container.
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If Meridia gives you an allergic reaction, you won't
be able to use it. You should also avoid Meridia (and
certainly don't need it) if you suffer from the compulsive
dieting disorder known as anorexia nervosa.
Do
not combine Meridia with other drugs used to suppress
appetite, and do not use it within 2 weeks of taking a drug
classified as an MAO inhibitor, including the antidepressant
medications Marplan, Nardil, and Parnate.
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Use Meridia with caution if you have uncontrolled high
blood pressure; it could make the problem worse. Avoid Meridia
completely if you've had a stroke or suffer from heart disease,
heart failure, or irregular heartbeat. Also
avoid it if you have severe kidney or liver problems; Meridia
has not been tested under these conditions.
Seizures
are a rare, but possible, side effect. If you've had seizures
in the past, use Meridia with caution. If you have
a seizure while taking the drug, stop using it and call your
doctor immediately.
Any drug that acts on the nervous system can theoretically
impair judgment, thinking, and motor skills. Meridia
does not seem to have this effect, but caution is still in
order until you know how the drug affects you. If you have
narrow-angle glaucoma or thyroid problems, make sure the doctor
knows; Meridia should be used with caution in these
circumstances.
If you are prone to gallstones, be aware that weight loss
can cause more of them to form. Meridia has not been
tested in people under 16 years old. Meridia should
be used with caution in those over 65. Although it has been
classified as a controlled substance (potentially subject
to abuse), the possibility of developing physical or psychological
dependence is low.
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Remember that Meridia must never be taken within 2
weeks of using an MAO inhibitor such as Marplan, Nardil, or
Parnate. The combination could lead to serious, even fatal,
overstimulation.
Meridia
may also interact with a wide variety of other prescription
and over-the-counter drugs, especially weight-reducing agents,
decongestants, antidepressants, allergy medications, and cough
suppressants that contain ephedrine, phenylpropanolamine,
or pseudoephedrine. Among the many drugs that pose a potential
problem are the following:
| Alcohol
(excessive amounts) |
Dextromethorphan
(found in many over-the-counter cough preparations) |
| Dihydroergotamine
(D.H.E. Injection, Migranal Nasal Spray) |
Erythromycin
(Eryc, Ery-Tab, PCE) |
Fentanyl
(Duragesic)
Fluoxetine (Prozac) |
Fluvoxamine
(Luvox) |
| Ketoconazole
(Nizoral) |
Lithium
(Lithobid, Lithonate) |
| Meperidine
(Demerol) |
Naratriptan
(Amerge) |
| Paroxetine
(Paxil) |
Pentazocine
(Talwin NX, Talacen) |
| Sertraline
(Zoloft) |
Stimulants
such as amphetamines, Dexedrine, Desoxyn, Adderall, Didrex,
and Ionamin |
| Sumatriptan
(Imitrex) |
Tryptophan
(L-Tryptophan, Trofan) |
| Venlafaxine
(Effexor) |
Zolmitriptan
(Zomig) |
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Side effects cannot be anticipated. If any develop or change
in intensity, inform your doctor as soon as possible. Only your
doctor can determine if it is safe for you to continue taking
Meridia.
More
common side effects may include: Abdominal pain, acid indigestion,
anxiety, back pain, constipation, cough increase, depression,
dizziness, dry mouth, flu symptoms, headache, increased appetite,
insomnia, joint pain, loss of appetite, loss of strength,
nasal inflammation, nausea, nervousness, painful menstruation,
rash, sinus inflammation, stomachache, sore throat
Less
common side effects may include: Acne, abnormal thinking,
agitation, allergic reaction, arthritis, bronchitis, changes
in taste, chest pain, dental problems, diarrhea, difficulty
breathing, drowsiness, ear pain, ear problems, emotional changes,
fever,gas, heavy uterine bleeding, herpes simplex virus, increased
heart rate, increased blood pressure, itching, laryngitis,
leg cramps, menstrual problems, migraine headache, muscle
ache, neck pain, rectal problems, reduced vision, stimulation,
stomach and intestinal inflammation, sweating, swelling, thirst,
throbbing heartbeat, tingling skin sensation, urinary tract
infection, vaginal yeast infection, vomiting
Rare
side effects may include: Bleeding problems, kidney problems,
seizures
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The use of Meridia during pregnancy is not recommended.
If you are in your childbearing years, take reliable contraceptive
measures while using this drug. If you do become pregnant, or
plan on becoming pregnant, tell your doctor immediately. It
is not known whether Meridia appears in breast milk;
its use while breast-feeding is not recommended. |
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Adults:
The starting dose is 10 milligrams of Meridia once daily.
If you have not lost at least 4 pounds after 4 weeks, the doctor
may increase the dose to 15 milligrams daily. This is the maximum;
if weight loss still fails to appear, Meridia will be
discontinued.
For those who experience side effects at the 10-milligram level,
a 5-milligram dose may prove sufficient. Use of Meridia
for longer than 1 year has not been studied. |
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Although doctors have had little experience with overdoses of
Meridia, increased heart rate and blood pressure are
possible results. Since any medication taken in excess can have
serious consequences, seek medical attention immediately if
you suspect an overdose.
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